What are the Reasons of Spontaneous Abortion?

by Yang Wenting on March 20, 2011

  1. Genetic defects Spouse with chromosomal abnormalities can transmit to the fetus, and then cause abortion. There are about 50~60% fetus with chromosomal abnormalities will undergo spontaneous abortion. The chromosomal abnormalities can include:
    • Aneuploidy: Aneuploidy refers to an abnormal number of chromosomes, and is a type of chromosome abnormality, such as three-body, x single and Triploid.
    • Chromosome structural abnormalities: the chromosome structural abnormalities mostly refer to the breakdown of chromosome arm, inverted, deletions and translocations.

    A small number of embryos with chromosomal abnormalities in term time, will happen deformities or functional defect after birth.

  2. Maternal factors
    • Systemic diseases: Pregnant women suffering from infection, high fever, severe anemia, heart failure, chronic nephritis, and hypertension.
    • Genital abnormalities: Uterine malformation (Uterine dysplasia, double uterine, uterine septum), Uterine cancer such as sub mucosal fibroids, Severe cervical trauma and relaxation of the cervix
    • Endocrine abnormalities: Hypothyroidism, Severe diabetes, Luteal phase defect
    • Bad habits: Smoking, alcohol, drug such as heroin
    • Trauma and stimulus: Serves shock and uterine trauma, Overstrain, anxiety, fear and sad
  3. Immune dysfunction The immune factors for the spontaneous abortion may include:
    • Paternal histocompatibility antigens
    • Fetus antigens
    • Blood group antigens (ABO and Rh)
    • The lack of maternal blocking antibodies during pregnancy
    • Anti-sperm antibodies
    • ……
  4. Environmental factors Pregnant woman excessively expose to chemical substances such as arsenic, lead, formaldehyde, benzene, chloroprene, ethylene oxide and so on.

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